Club Cerro Porteño vs. SE Palmeiras

Palmeiras enter this Copa Libertadores round-of-16 first leg at home with the edge in the market, driven by their status as Brazilian Série A leaders and superior squad depth despite multiple absences including Gustavo Gómez, Paulinho, Bruno Fuchs, and others with thigh or muscular issues. Cerro Porteño, who topped the shared group stage ahead of their opponents and secured a 1-0 victory at the same venue in May, benefit from a clean injury sheet and proven ability to compete in knockout ties against Brazilian sides. Recent domestic form shows Palmeiras with mixed results and Cerro struggling in the Paraguayan Clausura, keeping the implied probability of a home win only modestly ahead of a draw while leaving realistic scope for an away result.